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HCTU   CAS Number: 330645-87-9
   
 
HCTU
     
Application HCTU is an aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superior results to TBTU in the synthesis of difficult peptides, in hindered couplings, and cyclizations.
     
Chemical Name 2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium haxafluorophosphate;
1H-Benzotriazolium 1-[bis(dimethylamino)methylene]-5chloro-,hexafluorophosphate (1-),3-oxide
     
Chemical Data
 CAS No. 330645-87-9
Molecular Formula C11H15CIF6N5OP
Molecular Weight 413.69 g/mol
     
Typical Properties Appearance: White to off-white powder
Purity (HPLC): >99%
Melting Point: >185ºC
Solubility (20ºC): 28 % (wt./vol.) in DMF
0.08 % in EtOAc.
     
Storage Recommendations Store below 25ºC.
Keep dry.
Do not expose to light.
     
Files
 (click to download)
Specification
Assessment of 6Cl-HOBt-based coupling reagents in solid-phase cyclopeptide synthesis
Industrial application of coupling reagents in peptides

 

 

 

 

 

 

 

 

 

 

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