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PyClocK CAS Number: 893413-42-8

Application

PyClocK® has been reported to be faster than PyBOP® in
activating hindered amino acids such as Fmoc-Aib-OH,
and in some cases its reactivity was close to the most active
reagent, PyAOP®.
PyClock, as other phosphonium salts, can not react with free amine function and therefore does not terminate the peptide growing as the aminium salts do, through the formation of guanidine derivatives. Thus, PyClock is specially useful for slow coupling reactions and it can be used in excess to assure a complete activation of the carboxylic function.

Chemical Name

6-Chloro-Benzotriazole-1-yl-oxy-tris-Pyrrolidino-
Phosphonium Hexafluorophosphate

Chemical Data

Molecular wt: 554.84 g/mol

Typical Properties

Storage Recommendations

Keep cool and dry

Files
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Poster

Luxembourg BioTechnologies Ltd.
2 Bergman St. Rehovot 76705, Israel Phone: +972-8-946 6040 Fax: +972-8-946 6402 E-mail: main@peptide-and-dna.com